We are in constant pursuit of breakthroughs that transform patients' lives. We create innovations daily to make the world a healthier place. This was Charles Pfizer's initial vision, and it holds true today. Evidence confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best professionals, and know how to unleash the power of those individuals. Pfizer's purpose—Breakthroughs that change patients' lives—fuels everything we do and shows our passion for expanding our legacy as one of the most important contributors of good to the world. Each word in our purpose has significance and embodies the value we work to bring to patients and society. Our purpose guarantees that patients continue to be at the centre of all we do. We fulfill our purpose by seeking the best science in the world, working with others in the healthcare system to improve access to our medicines, employing digital technologies to improve our drug discovery and development, as well as patient outcomes, and spearheading the conversation to push for pro-innovation/pro-patient policies. Every choice we make, and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.